“The Substance” was lauded upon its premiere at the Cannes Film Festival earlier this year, where it was up for the Palme d’Or and won the best screenplay award. Earlier this month, it took home the Midnight Madness people’s choice award at the Toronto International Film Fest. “The Substance” is currently playing in theaters.

Demi Moore was a troubled member of the "Brat Pack," who overcame esteem issues and became the highest-paid actress in Hollywood, starring in such films as "Indecent Proposal," "Charlie's Angels" and "Striptease.

The new body-horror movie "The Substance" is a wild time, It also took co-stars Demi Moore and Margaret Qualley way out of their comfort zones.