No. 18 Michigan inflicted a pair of significant blows in the first half against No. 11 USC on Saturday, taking a 14-3 lead into the break behind stingy defense and explosiveness in its run game. Kalel Mullings busted a 53-yard touchdown run on the Wolverines' third possession to open the scoring after the teams traded early punts.

An active and potentially impactful Week 4 college football schedule kicks off today around the country, with marquee matchups involving ranked teams in the SEC, Big Ten, and Big 12. Here is your guide to the most important games on the schedule today involving schools in the top 25 rankings,