Live updates as the No. 11 USC Trojans face off against the No. 18 Michigan Wolverines on Saturday, Sept. 21 at 3:30 p.m. PDT. USC coach Lincoln Riley and his team look to pick up their second win over a ranked opponent.

Ranked No. 18 Michigan football will be without one of its top players in a highly anticipated game against the No. 11 USC Trojans. Junior tight end Colston Loveland (shoulder) has been ruled out ahead of Saturday's game (3:30 p.m. EST), according to the team's availability report via Nicole Auerbach of NBC Sports.

Though it didn’t earn the “College GameDay” treatment — ESPN’s popular pregame show was broadcasting from Norman, Oklahoma ahead of Saturday night’s game between No. 13 Oklahoma and No. 7 Tennessee — the game between Michigan and USC is one of the biggest on the Week 4 calendar.